Login now to access Regular content available to all registered users.
Abstract
Discussion Forum (0)
Utility of Plasma Neurofilament Light Chain in Determining Subclinical Disease Activity in Chronic Inflammatory Demyelinating Polyradiculoneuropathy
Poster No: 1130
Presenter: Mahima Kapoor
Institution: Alfred Hospital, Monash University
Introduction: To explore associations between plasma neurofilament light chain (pNfL) and disease activity in patients with chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) and examine its usefulness in determining disease remission.
Methods: We examined pNfL in untreated CIDP patients (n=10) before and after intravenous immunoglobulin (IVIg) induction treatment, differences in pNfL in patients on maintenance IVIg treatment (stable patients n=15, unstable patients n=9), and in clinically stable IVIg treated patients (n=10) in whom we stopped IVIg to determine their disease activity and need for maintenance IVIg.
Results: Untreated patients with CIDP: pNfL was significantly higher in patients than an age-matched, healthy control group and comparable to control group values post IVIg induction. Clinically stable and unstable patients with CIDP on IVIg treatment: pNfL was significantly greater in unstable patients than stable patients. A pNFL value above 16.6 pg/mL identified unstable treated CIDP from stable treated CIDP (sensitivity= 86.7%, specificity= 66.7%, area under ROC= 0.73). Treatment withdrawal group: There was a strong and statistically significant correlation between pNfL concentration at time of IVIg withdrawal and the occurrence of relapse, suggesting an association of higher pNfL with active disease.
Conclusions: pNfL concentrations may be a sensitive, clinically useful biomarker in assessing subclinical disease activity.
References: No
References 1:
References 2:
References 3:
References 4:
Grant Support:
Keywords: neurofilament light chain, CIDP, disease activity, remission
Poster No: 1130
Presenter: Mahima Kapoor
Institution: Alfred Hospital, Monash University
Introduction: To explore associations between plasma neurofilament light chain (pNfL) and disease activity in patients with chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) and examine its usefulness in determining disease remission.
Methods: We examined pNfL in untreated CIDP patients (n=10) before and after intravenous immunoglobulin (IVIg) induction treatment, differences in pNfL in patients on maintenance IVIg treatment (stable patients n=15, unstable patients n=9), and in clinically stable IVIg treated patients (n=10) in whom we stopped IVIg to determine their disease activity and need for maintenance IVIg.
Results: Untreated patients with CIDP: pNfL was significantly higher in patients than an age-matched, healthy control group and comparable to control group values post IVIg induction. Clinically stable and unstable patients with CIDP on IVIg treatment: pNfL was significantly greater in unstable patients than stable patients. A pNFL value above 16.6 pg/mL identified unstable treated CIDP from stable treated CIDP (sensitivity= 86.7%, specificity= 66.7%, area under ROC= 0.73). Treatment withdrawal group: There was a strong and statistically significant correlation between pNfL concentration at time of IVIg withdrawal and the occurrence of relapse, suggesting an association of higher pNfL with active disease.
Conclusions: pNfL concentrations may be a sensitive, clinically useful biomarker in assessing subclinical disease activity.
References: No
References 1:
References 2:
References 3:
References 4:
Grant Support:
Keywords: neurofilament light chain, CIDP, disease activity, remission
Utility of Plasma Neurofilament Light Chain in Determining Subclinical Disease Activity in Chronic Inflammatory Demyelinating Polyradiculoneuropathy
Poster No: 1130
Presenter: Mahima Kapoor
Institution: Alfred Hospital, Monash University
Introduction: To explore associations between plasma neurofilament light chain (pNfL) and disease activity in patients with chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) and examine its usefulness in determining disease remission.
Methods: We examined pNfL in untreated CIDP patients (n=10) before and after intravenous immunoglobulin (IVIg) induction treatment, differences in pNfL in patients on maintenance IVIg treatment (stable patients n=15, unstable patients n=9), and in clinically stable IVIg treated patients (n=10) in whom we stopped IVIg to determine their disease activity and need for maintenance IVIg.
Results: Untreated patients with CIDP: pNfL was significantly higher in patients than an age-matched, healthy control group and comparable to control group values post IVIg induction. Clinically stable and unstable patients with CIDP on IVIg treatment: pNfL was significantly greater in unstable patients than stable patients. A pNFL value above 16.6 pg/mL identified unstable treated CIDP from stable treated CIDP (sensitivity= 86.7%, specificity= 66.7%, area under ROC= 0.73). Treatment withdrawal group: There was a strong and statistically significant correlation between pNfL concentration at time of IVIg withdrawal and the occurrence of relapse, suggesting an association of higher pNfL with active disease.
Conclusions: pNfL concentrations may be a sensitive, clinically useful biomarker in assessing subclinical disease activity.
References: No
References 1:
References 2:
References 3:
References 4:
Grant Support:
Keywords: neurofilament light chain, CIDP, disease activity, remission
Poster No: 1130
Presenter: Mahima Kapoor
Institution: Alfred Hospital, Monash University
Introduction: To explore associations between plasma neurofilament light chain (pNfL) and disease activity in patients with chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) and examine its usefulness in determining disease remission.
Methods: We examined pNfL in untreated CIDP patients (n=10) before and after intravenous immunoglobulin (IVIg) induction treatment, differences in pNfL in patients on maintenance IVIg treatment (stable patients n=15, unstable patients n=9), and in clinically stable IVIg treated patients (n=10) in whom we stopped IVIg to determine their disease activity and need for maintenance IVIg.
Results: Untreated patients with CIDP: pNfL was significantly higher in patients than an age-matched, healthy control group and comparable to control group values post IVIg induction. Clinically stable and unstable patients with CIDP on IVIg treatment: pNfL was significantly greater in unstable patients than stable patients. A pNFL value above 16.6 pg/mL identified unstable treated CIDP from stable treated CIDP (sensitivity= 86.7%, specificity= 66.7%, area under ROC= 0.73). Treatment withdrawal group: There was a strong and statistically significant correlation between pNfL concentration at time of IVIg withdrawal and the occurrence of relapse, suggesting an association of higher pNfL with active disease.
Conclusions: pNfL concentrations may be a sensitive, clinically useful biomarker in assessing subclinical disease activity.
References: No
References 1:
References 2:
References 3:
References 4:
Grant Support:
Keywords: neurofilament light chain, CIDP, disease activity, remission
Utility of Plasma Neurofilament Light Chain in Determining Subclinical Disease Activity in Chronic Inflammatory Demyelinating Polyradiculoneuropathy
Dr. Mahima Kapoor
Abstract
Discussion Forum (0)
Utility of Plasma Neurofilament Light Chain in Determining Subclinical Disease Activity in Chronic Inflammatory Demyelinating Polyradiculoneuropathy
Poster No: 1130
Presenter: Mahima Kapoor
Institution: Alfred Hospital, Monash University
Introduction: To explore associations between plasma neurofilament light chain (pNfL) and disease activity in patients with chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) and examine its usefulness in determining disease remission.
Methods: We examined pNfL in untreated CIDP patients (n=10) before and after intravenous immunoglobulin (IVIg) induction treatment, differences in pNfL in patients on maintenance IVIg treatment (stable patients n=15, unstable patients n=9), and in clinically stable IVIg treated patients (n=10) in whom we stopped IVIg to determine their disease activity and need for maintenance IVIg.
Results: Untreated patients with CIDP: pNfL was significantly higher in patients than an age-matched, healthy control group and comparable to control group values post IVIg induction. Clinically stable and unstable patients with CIDP on IVIg treatment: pNfL was significantly greater in unstable patients than stable patients. A pNFL value above 16.6 pg/mL identified unstable treated CIDP from stable treated CIDP (sensitivity= 86.7%, specificity= 66.7%, area under ROC= 0.73). Treatment withdrawal group: There was a strong and statistically significant correlation between pNfL concentration at time of IVIg withdrawal and the occurrence of relapse, suggesting an association of higher pNfL with active disease.
Conclusions: pNfL concentrations may be a sensitive, clinically useful biomarker in assessing subclinical disease activity.
References: No
References 1:
References 2:
References 3:
References 4:
Grant Support:
Keywords: neurofilament light chain, CIDP, disease activity, remission
Poster No: 1130
Presenter: Mahima Kapoor
Institution: Alfred Hospital, Monash University
Introduction: To explore associations between plasma neurofilament light chain (pNfL) and disease activity in patients with chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) and examine its usefulness in determining disease remission.
Methods: We examined pNfL in untreated CIDP patients (n=10) before and after intravenous immunoglobulin (IVIg) induction treatment, differences in pNfL in patients on maintenance IVIg treatment (stable patients n=15, unstable patients n=9), and in clinically stable IVIg treated patients (n=10) in whom we stopped IVIg to determine their disease activity and need for maintenance IVIg.
Results: Untreated patients with CIDP: pNfL was significantly higher in patients than an age-matched, healthy control group and comparable to control group values post IVIg induction. Clinically stable and unstable patients with CIDP on IVIg treatment: pNfL was significantly greater in unstable patients than stable patients. A pNFL value above 16.6 pg/mL identified unstable treated CIDP from stable treated CIDP (sensitivity= 86.7%, specificity= 66.7%, area under ROC= 0.73). Treatment withdrawal group: There was a strong and statistically significant correlation between pNfL concentration at time of IVIg withdrawal and the occurrence of relapse, suggesting an association of higher pNfL with active disease.
Conclusions: pNfL concentrations may be a sensitive, clinically useful biomarker in assessing subclinical disease activity.
References: No
References 1:
References 2:
References 3:
References 4:
Grant Support:
Keywords: neurofilament light chain, CIDP, disease activity, remission
Utility of Plasma Neurofilament Light Chain in Determining Subclinical Disease Activity in Chronic Inflammatory Demyelinating Polyradiculoneuropathy
Poster No: 1130
Presenter: Mahima Kapoor
Institution: Alfred Hospital, Monash University
Introduction: To explore associations between plasma neurofilament light chain (pNfL) and disease activity in patients with chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) and examine its usefulness in determining disease remission.
Methods: We examined pNfL in untreated CIDP patients (n=10) before and after intravenous immunoglobulin (IVIg) induction treatment, differences in pNfL in patients on maintenance IVIg treatment (stable patients n=15, unstable patients n=9), and in clinically stable IVIg treated patients (n=10) in whom we stopped IVIg to determine their disease activity and need for maintenance IVIg.
Results: Untreated patients with CIDP: pNfL was significantly higher in patients than an age-matched, healthy control group and comparable to control group values post IVIg induction. Clinically stable and unstable patients with CIDP on IVIg treatment: pNfL was significantly greater in unstable patients than stable patients. A pNFL value above 16.6 pg/mL identified unstable treated CIDP from stable treated CIDP (sensitivity= 86.7%, specificity= 66.7%, area under ROC= 0.73). Treatment withdrawal group: There was a strong and statistically significant correlation between pNfL concentration at time of IVIg withdrawal and the occurrence of relapse, suggesting an association of higher pNfL with active disease.
Conclusions: pNfL concentrations may be a sensitive, clinically useful biomarker in assessing subclinical disease activity.
References: No
References 1:
References 2:
References 3:
References 4:
Grant Support:
Keywords: neurofilament light chain, CIDP, disease activity, remission
Poster No: 1130
Presenter: Mahima Kapoor
Institution: Alfred Hospital, Monash University
Introduction: To explore associations between plasma neurofilament light chain (pNfL) and disease activity in patients with chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) and examine its usefulness in determining disease remission.
Methods: We examined pNfL in untreated CIDP patients (n=10) before and after intravenous immunoglobulin (IVIg) induction treatment, differences in pNfL in patients on maintenance IVIg treatment (stable patients n=15, unstable patients n=9), and in clinically stable IVIg treated patients (n=10) in whom we stopped IVIg to determine their disease activity and need for maintenance IVIg.
Results: Untreated patients with CIDP: pNfL was significantly higher in patients than an age-matched, healthy control group and comparable to control group values post IVIg induction. Clinically stable and unstable patients with CIDP on IVIg treatment: pNfL was significantly greater in unstable patients than stable patients. A pNFL value above 16.6 pg/mL identified unstable treated CIDP from stable treated CIDP (sensitivity= 86.7%, specificity= 66.7%, area under ROC= 0.73). Treatment withdrawal group: There was a strong and statistically significant correlation between pNfL concentration at time of IVIg withdrawal and the occurrence of relapse, suggesting an association of higher pNfL with active disease.
Conclusions: pNfL concentrations may be a sensitive, clinically useful biomarker in assessing subclinical disease activity.
References: No
References 1:
References 2:
References 3:
References 4:
Grant Support:
Keywords: neurofilament light chain, CIDP, disease activity, remission
{{ help_message }}
{{filter}}