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Abstract
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Comparison of combined morphological and quantitative biomarkers obtained with high-field MRI in sciatic nerves of CMT1A patients and healthy controls
Poster No: 1234
Presenter: REZA Sadjadi
Institution: MGH/Harvard University
Introduction: Patients with peripheral nerve disease such as Charcot-Marie-Tooth (CMT) syndrome are thought to exhibit various anatomic differences from healthy controls. Some of these differences are morphological, such as nerve cross-sectional areas, while others reflect microscopic differences. With high-resolution magnetic resonance imaging (MRI), morphological changes can be visualized, but imaging of microstructural tissue changes often requires specialized quantitative MRI. Here, we combine morphological and quantitative MRI in one imaging method. We compare the results in CMT1A patients and healthy controls.
Methods: Using a version of the Double-Echo in Steady-State (DESS) MRI sequence that allowed quantification of the MRI parameters of T2 relaxation, apparent diffusion coefficient (ADC), and fat fraction (FF), in addition to morphology, axial images were acquired in the lower right thigh of 6 CMT1A subjects and 6 age- and sex-matched healthy controls. Imaging was performed in a 7 Tesla MRI scanner, allowing a resolution below 0.15 mm and clear visualization of nerve fascicles. Quantitative parameter maps were produced at the same resolution. A slice was selected at the sciatic nerve bifurcation. By drawing regions of interest (ROIs) around individual fascicles, the fascicle cross-sectional area (CSA), T2, ADC, and FF were measured. This was repeated for the tibial and fibular nerves, 1 cm below the bifurcation slice. The results were compared between patients and controls. Statistical significance was determined using a two-sided t-test with α = 0.05.
Results: Images clearly displaying individual nerve fascicles and their quantitative measurements were obtained. The results indicated a larger CSA, T2, and ADC in CMT1A patients compared to controls, but only the difference in CSA was statistically significant.
Conclusions: Using simultaneous morphological and quantitative MRI at high resolution, we were able to obtain several measurements in peripheral nerve fascicles, some showing differences between patients and controls. This could contribute to establishing imaging biomarkers for peripheral nerve disease.
References: No
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References 2:
References 3:
References 4:
Grant Support: NIH K99AG066815; Research scholarship grant from the American Academy of Neurology (AAN)
Keywords: CMT1A, MRI, Biomarkers, Imaging, Quantitative
Poster No: 1234
Presenter: REZA Sadjadi
Institution: MGH/Harvard University
Introduction: Patients with peripheral nerve disease such as Charcot-Marie-Tooth (CMT) syndrome are thought to exhibit various anatomic differences from healthy controls. Some of these differences are morphological, such as nerve cross-sectional areas, while others reflect microscopic differences. With high-resolution magnetic resonance imaging (MRI), morphological changes can be visualized, but imaging of microstructural tissue changes often requires specialized quantitative MRI. Here, we combine morphological and quantitative MRI in one imaging method. We compare the results in CMT1A patients and healthy controls.
Methods: Using a version of the Double-Echo in Steady-State (DESS) MRI sequence that allowed quantification of the MRI parameters of T2 relaxation, apparent diffusion coefficient (ADC), and fat fraction (FF), in addition to morphology, axial images were acquired in the lower right thigh of 6 CMT1A subjects and 6 age- and sex-matched healthy controls. Imaging was performed in a 7 Tesla MRI scanner, allowing a resolution below 0.15 mm and clear visualization of nerve fascicles. Quantitative parameter maps were produced at the same resolution. A slice was selected at the sciatic nerve bifurcation. By drawing regions of interest (ROIs) around individual fascicles, the fascicle cross-sectional area (CSA), T2, ADC, and FF were measured. This was repeated for the tibial and fibular nerves, 1 cm below the bifurcation slice. The results were compared between patients and controls. Statistical significance was determined using a two-sided t-test with α = 0.05.
Results: Images clearly displaying individual nerve fascicles and their quantitative measurements were obtained. The results indicated a larger CSA, T2, and ADC in CMT1A patients compared to controls, but only the difference in CSA was statistically significant.
Conclusions: Using simultaneous morphological and quantitative MRI at high resolution, we were able to obtain several measurements in peripheral nerve fascicles, some showing differences between patients and controls. This could contribute to establishing imaging biomarkers for peripheral nerve disease.
References: No
References 1:
References 2:
References 3:
References 4:
Grant Support: NIH K99AG066815; Research scholarship grant from the American Academy of Neurology (AAN)
Keywords: CMT1A, MRI, Biomarkers, Imaging, Quantitative
Comparison of combined morphological and quantitative biomarkers obtained with high-field MRI in sciatic nerves of CMT1A patients and healthy controls
Poster No: 1234
Presenter: REZA Sadjadi
Institution: MGH/Harvard University
Introduction: Patients with peripheral nerve disease such as Charcot-Marie-Tooth (CMT) syndrome are thought to exhibit various anatomic differences from healthy controls. Some of these differences are morphological, such as nerve cross-sectional areas, while others reflect microscopic differences. With high-resolution magnetic resonance imaging (MRI), morphological changes can be visualized, but imaging of microstructural tissue changes often requires specialized quantitative MRI. Here, we combine morphological and quantitative MRI in one imaging method. We compare the results in CMT1A patients and healthy controls.
Methods: Using a version of the Double-Echo in Steady-State (DESS) MRI sequence that allowed quantification of the MRI parameters of T2 relaxation, apparent diffusion coefficient (ADC), and fat fraction (FF), in addition to morphology, axial images were acquired in the lower right thigh of 6 CMT1A subjects and 6 age- and sex-matched healthy controls. Imaging was performed in a 7 Tesla MRI scanner, allowing a resolution below 0.15 mm and clear visualization of nerve fascicles. Quantitative parameter maps were produced at the same resolution. A slice was selected at the sciatic nerve bifurcation. By drawing regions of interest (ROIs) around individual fascicles, the fascicle cross-sectional area (CSA), T2, ADC, and FF were measured. This was repeated for the tibial and fibular nerves, 1 cm below the bifurcation slice. The results were compared between patients and controls. Statistical significance was determined using a two-sided t-test with α = 0.05.
Results: Images clearly displaying individual nerve fascicles and their quantitative measurements were obtained. The results indicated a larger CSA, T2, and ADC in CMT1A patients compared to controls, but only the difference in CSA was statistically significant.
Conclusions: Using simultaneous morphological and quantitative MRI at high resolution, we were able to obtain several measurements in peripheral nerve fascicles, some showing differences between patients and controls. This could contribute to establishing imaging biomarkers for peripheral nerve disease.
References: No
References 1:
References 2:
References 3:
References 4:
Grant Support: NIH K99AG066815; Research scholarship grant from the American Academy of Neurology (AAN)
Keywords: CMT1A, MRI, Biomarkers, Imaging, Quantitative
Poster No: 1234
Presenter: REZA Sadjadi
Institution: MGH/Harvard University
Introduction: Patients with peripheral nerve disease such as Charcot-Marie-Tooth (CMT) syndrome are thought to exhibit various anatomic differences from healthy controls. Some of these differences are morphological, such as nerve cross-sectional areas, while others reflect microscopic differences. With high-resolution magnetic resonance imaging (MRI), morphological changes can be visualized, but imaging of microstructural tissue changes often requires specialized quantitative MRI. Here, we combine morphological and quantitative MRI in one imaging method. We compare the results in CMT1A patients and healthy controls.
Methods: Using a version of the Double-Echo in Steady-State (DESS) MRI sequence that allowed quantification of the MRI parameters of T2 relaxation, apparent diffusion coefficient (ADC), and fat fraction (FF), in addition to morphology, axial images were acquired in the lower right thigh of 6 CMT1A subjects and 6 age- and sex-matched healthy controls. Imaging was performed in a 7 Tesla MRI scanner, allowing a resolution below 0.15 mm and clear visualization of nerve fascicles. Quantitative parameter maps were produced at the same resolution. A slice was selected at the sciatic nerve bifurcation. By drawing regions of interest (ROIs) around individual fascicles, the fascicle cross-sectional area (CSA), T2, ADC, and FF were measured. This was repeated for the tibial and fibular nerves, 1 cm below the bifurcation slice. The results were compared between patients and controls. Statistical significance was determined using a two-sided t-test with α = 0.05.
Results: Images clearly displaying individual nerve fascicles and their quantitative measurements were obtained. The results indicated a larger CSA, T2, and ADC in CMT1A patients compared to controls, but only the difference in CSA was statistically significant.
Conclusions: Using simultaneous morphological and quantitative MRI at high resolution, we were able to obtain several measurements in peripheral nerve fascicles, some showing differences between patients and controls. This could contribute to establishing imaging biomarkers for peripheral nerve disease.
References: No
References 1:
References 2:
References 3:
References 4:
Grant Support: NIH K99AG066815; Research scholarship grant from the American Academy of Neurology (AAN)
Keywords: CMT1A, MRI, Biomarkers, Imaging, Quantitative
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